Reaction Details  Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50551596
Substrate
n/a
Meas. Tech.
ChEMBL_2031892 (CHEMBL4686050)
IC50
>10000±n/a nM
Citation
 Wu, WC; Liu, YM; Lin, MH; Liao, YH; Lai, MJ; Chuang, HY; Hung, TY; Chen, CH; Liou, JP Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response. Eur J Med Chem 192:0 (2020) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50551596
Synonyms:
CHEMBL4788251
Type:
Small organic molecule
Emp. Form.:
C28H27N3O4S
Mol. Mass.:
501.597
SMILES:
COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CCc1ccc(cc1)C(=O)Nc1ccccc1N
Structure:
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