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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50111348
Substrate
n/a
Meas. Tech.
ChEBML_139766
Ki
17±n/a nM
Citation
 Wang, Y; Chackalamannil, S; Hu, Z; McKittrick, BA; Greenlee, W; Ruperto, V; Duffy, RA; Lachowicz, JE Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists. Bioorg Med Chem Lett 12:1087-91 (2002) [PubMed]
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50111348
Synonyms:
CHEMBL12150 | Naphthalen-1-yl-{4-[4-(propane-2-sulfonyl)-benzyl]-[1,4']bipiperidinyl-1'-yl}-methanone
Type:
Small organic molecule
Emp. Form.:
C31H38N2O3S
Mol. Mass.:
518.71
SMILES:
CC(C)S(=O)(=O)c1ccc(CC2CCN(CC2)C2CCN(CC2)C(=O)c2cccc3ccccc23)cc1
Structure:
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