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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM50111434
Substrate
n/a
Meas. Tech.
ChEBML_221498
IC50
>250000±n/a nM
Citation
 Song, Y; Wang, J; Teng, SF; Kesuma, D; Deng, Y; Duan, J; Wang, JH; Qi, RZ; Sim, MM Beta-carbolines as specific inhibitors of cyclin-dependent kinases. Bioorg Med Chem Lett 12:1129-32 (2002) [PubMed]
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM50111434
Synonyms:
1-(5-Methyl-1H-imidazol-4-yl)-9H-beta-carboline | CHEMBL273547
Type:
Small organic molecule
Emp. Form.:
C15H12N4
Mol. Mass.:
248.2826
SMILES:
Cc1[nH]cnc1-c1[nH]ccc2c3ccccc3nc12
Structure:
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