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Target
Carbonic anhydrase 2
Ligand
BDBM50552013
Substrate
n/a
Meas. Tech.
ChEMBL_2032949 (CHEMBL4687107)
Ki
67700±n/a nM
Citation
 Sa?l?k, BN; Osmaniye, D; Çevik, UA; Levent, S; Çavu?o?lu, BK; Büyükemir, O; Nezir, D; Karaduman, AB; Özkay, Y; Koparal, AS; Beydemir, ?; Kaplanc?kl?, ZA Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate. Eur J Med Chem 198:0 (2020) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50552013
Synonyms:
CHEMBL4761403
Type:
Small organic molecule
Emp. Form.:
C21H26N4O4S3
Mol. Mass.:
494.651
SMILES:
COc1ccc(CN2CCN(CC2)C(=S)SCC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Structure:
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