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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50552146
Substrate
n/a
Meas. Tech.
ChEMBL_2033679 (CHEMBL4687837)
IC50
5.2±n/a nM
Citation
 Quevedo, CE; Bataille, CJR; Byrne, S; Durbin, M; Elkins, J; Guillermo, A; Jones, AM; Knapp, S; Nadali, A; Walker, RG; Wilkinson, IVL; Wynne, GM; Davies, SG; Russell, AJ Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family. Bioorg Med Chem 28:0 (2020) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50552146
Synonyms:
CHEMBL4747343
Type:
Small organic molecule
Emp. Form.:
C19H18FN3O3S2
Mol. Mass.:
419.493
SMILES:
OC[C@H]1CCC[C@@H]1NC1=NC(=O)\C(S1)=C\c1csc(n1)-c1cccc(F)c1O |r,t:9|
Structure:
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