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Target
Neutrophil collagenase
Ligand
BDBM50111997
Substrate
n/a
Meas. Tech.
ChEBML_105204
Ki
1500±n/a nM
Citation
 Krumme, D; Tschesche, H Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases. Bioorg Med Chem Lett 12:933-6 (2002) [PubMed]
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50111997
Synonyms:
CHEMBL366997 | N-[(S)-2-(4-Benzyloxy-phenyl)-1-methylcarbamoyl-ethyl]-N'-hydroxy-oxalamide
Type:
Small organic molecule
Emp. Form.:
C19H21N3O5
Mol. Mass.:
371.3871
SMILES:
CNC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(=O)NO
Structure:
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