Reaction Details  Report a problem with these data
Target
Dual specificity protein kinase CLK2
Ligand
BDBM50552555
Substrate
n/a
Meas. Tech.
ChEMBL_2035042 (CHEMBL4689200)
IC50
27±n/a nM
Citation
 Brahmaiah, D; Kanaka Durga Bhavani, A; Aparna, P; Sampath Kumar, N; Solhi, H; Le Guevel, R; Baratte, B; Ruchaud, S; Bach, S; Singh Jadav, S; Raji Reddy, C; Roisnel, T; Mosset, P; Levoin, N; Grée, R Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase. Bioorg Med Chem 31:0 (2021) [PubMed]  Article
Target
Name:
Dual specificity protein kinase CLK2
Synonyms:
2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN
Type:
n/a
Mol. Mass.:
60128.79
Organism:
Homo sapiens (Human)
Description:
P49760
Residue:
499
Sequence:
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
  
Inhibitor
Name:
BDBM50552555
Synonyms:
CHEMBL4783398
Type:
Small organic molecule
Emp. Form.:
C24H18ClN7O3
Mol. Mass.:
487.898
SMILES:
Cc1ccc(c(c1)[N+]([O-])=O)-n1cc(COc2cccc3cnc(Nc4cccc(Cl)c4)nc23)nn1
Structure:
Search PDB for entries with ligand similarity: