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Target
Proteasome subunit beta type-5
Ligand
BDBM50554365
Substrate
n/a
Meas. Tech.
ChEMBL_2049562 (CHEMBL4704261)
IC50
101±n/a nM
Citation
 Zhan, W; Singh, PK; Ban, Y; Qing, X; Ah Kioon, MD; Fan, H; Zhao, Q; Wang, R; Sukenick, G; Salmon, J; Warren, JD; Ma, X; Barrat, FJ; Nathan, CF; Lin, G Structure-Activity Relationships of Noncovalent Immunoproteasome ?5i-Selective Dipeptides. J Med Chem 63:13103-13123 (2020) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50554365
Synonyms:
CHEMBL4764833
Type:
Small organic molecule
Emp. Form.:
C29H40N4O7
Mol. Mass.:
556.6505
SMILES:
COC[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc(OC)c1 |r|
Structure:
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