Reaction Details  Report a problem with these data
Target
Polyamine deacetylase HDAC10
Ligand
BDBM50555464
Substrate
n/a
Meas. Tech.
ChEMBL_2052192 (CHEMBL4707193)
IC50
2.3±n/a nM
Citation
 Chen, D; Soh, CK; Goh, WH; Wang, H Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma. J Med Chem 61:1552-1575 (2018) [PubMed]  Article
Target
Name:
Polyamine deacetylase HDAC10
Synonyms:
HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
71431.89
Organism:
Homo sapiens (Human)
Description:
Q969S8
Residue:
669
Sequence:
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
  
Inhibitor
Name:
BDBM50555464
Synonyms:
CHEMBL4744689
Type:
Small organic molecule
Emp. Form.:
C21H28N8O3
Mol. Mass.:
440.4988
SMILES:
Nc1ncc(cn1)-c1nc(N2CCOCC2)c2ccn(CCCCCCC(=O)NO)c2n1
Structure:
Search PDB for entries with ligand similarity: