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Target
Histone deacetylase 11
Ligand
BDBM50105330
Substrate
n/a
Meas. Tech.
ChEMBL_2052193 (CHEMBL4707194)
IC50
>10000±n/a nM
Citation
 Chen, D; Soh, CK; Goh, WH; Wang, H Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma. J Med Chem 61:1552-1575 (2018) [PubMed]  Article
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50105330
Synonyms:
CHEMBL1851943
Type:
Small organic molecule
Emp. Form.:
C20H30N4O2
Mol. Mass.:
358.4778
SMILES:
CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Structure:
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