Reaction Details  Report a problem with these data
Target
1-phosphatidylinositol phosphodiesterase
Ligand
BDBM50555558
Substrate
n/a
Meas. Tech.
ChEMBL_2052536 (CHEMBL4707537)
IC50
3100±n/a nM
Citation
 Eurtivong, C; Pilkington, LI; van Rensburg, M; White, RM; Brar, HK; Rees, S; Paulin, EK; Xu, CS; Sharma, N; Leung, IKH; Leung, E; Barker, D; Reynisson, J Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. Eur J Med Chem 187:0 (2020) [PubMed]  Article
Target
Name:
1-phosphatidylinositol phosphodiesterase
Synonyms:
1-phosphatidylinositol phosphodiesterase | 4.6.1.13 | PI-PLC | PLC_BACCE | Phosphatidylinositol diacylglycerol-lyase | Phosphatidylinositol-specific phospholipase C
Type:
PROTEIN
Mol. Mass.:
38110.25
Organism:
Bacillus cereus
Description:
ChEMBL_120142
Residue:
329
Sequence:
MSNKKLILKLFICSTIFITFVFALHDKRVVAASSVNELENWSKWMQPIPDSIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVGWVIQDYINEKWSPLLYQEVIRANKSLIKE
  
Inhibitor
Name:
BDBM50555558
Synonyms:
CHEMBL3945790
Type:
Small organic molecule
Emp. Form.:
C18H16N2O4
Mol. Mass.:
324.3306
SMILES:
OC(=O)C1Cc2c([nH]c3ccccc23)C(N1)c1ccc(O)c(O)c1
Structure:
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