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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM43362
Substrate
n/a
Meas. Tech.
ChEMBL_2053890 (CHEMBL4708891)
IC50
2290±n/a nM
Citation
 Xu, YX; Huang, YY; Song, RR; Ren, YL; Chen, X; Zhang, C; Mao, F; Li, XK; Zhu, J; Ni, SS; Wan, J; Li, J Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem 203:0 (2020) [PubMed]  Article
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM43362
Synonyms:
MLS000069752 | N,N-dimethylcarbamodithioic acid (dimethylthiocarbamoylthio) ester | N,N-dimethylcarbamodithioic acid [[dimethylamino(sulfanylidene)methyl]thio] ester | SMR000059023 | TETRAMETHYLTHIURAM DISULFIDE | cid_5455 | dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate
Type:
Small organic molecule
Emp. Form.:
C6H12N2S4
Mol. Mass.:
240.433
SMILES:
CN(C)C(=S)SSC(=S)N(C)C
Structure:
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