Reaction Details 
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Histamine H3 receptor
Ligand
BDBM50556117
Substrate
n/a
Meas. Tech.
ChEMBL_2054933 (CHEMBL4709934)
Ki
282±n/a nM
Citation
?a?ewska, D; Bajda, M; Kaleta, M; Zar?ba, P; Doroz-P?onka, A; Siwek, A; Alachkar, A; Mogilski, S; Saad, A; Kuder, K; Olejarz-Maciej, A; Gody?, J; Stary, D; Sudo?, S; Wi?cek, M; Latacz, G; Walczak, M; Handzlik, J; Sadek, B; Malawska, B; Kie?-Kononowicz, K Rational design of new multitarget histamine H Eur J Med Chem 207:0 (2020) [PubMed] ArticleMore Info.:
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
Inhibitor
Name:
BDBM50556117
Synonyms:
CHEMBL4785098
Type:
Small organic molecule
Emp. Form.:
C24H28ClNO3
Mol. Mass.:
413.937
SMILES:
Clc1ccc2oc3ccc(OCCCCCCN4CCCCC4)cc3c(=O)c2c1
Structure:
