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Target
Casein kinase II subunit alpha'
Ligand
BDBM50556137
Substrate
n/a
Meas. Tech.
ChEMBL_2055110 (CHEMBL4710111)
IC50
7640±n/a nM
Citation
 Krämer, A; Kurz, CG; Berger, BT; Celik, IE; Tjaden, A; Greco, FA; Knapp, S; Hanke, T Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor. Eur J Med Chem 208:0 (2020) [PubMed]  Article
Target
Name:
Casein kinase II subunit alpha'
Synonyms:
CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2)
Type:
Protein
Mol. Mass.:
41223.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
350
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
  
Inhibitor
Name:
BDBM50556137
Synonyms:
CHEMBL4793819
Type:
Small organic molecule
Emp. Form.:
C22H26N4O7
Mol. Mass.:
458.4644
SMILES:
CC(C)(C)OC(=O)N(CCOCCO)c1ccn2ncc(-c3ccc(C(O)=O)c(O)c3)c2n1
Structure:
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