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Target
Mitogen-activated protein kinase kinase kinase 20
Ligand
BDBM50556597
Substrate
n/a
Meas. Tech.
ChEMBL_2056716 (CHEMBL4711717)
Kd
120±n/a nM
Citation
 Röhm, S; Schröder, M; Dwyer, JE; Widdowson, CS; Chaikuad, A; Berger, BT; Joerger, AC; Krämer, A; Harbig, J; Dauch, D; Kudolo, M; Laufer, S; Bagley, MC; Knapp, S Selective targeting of the ?C and DFG-out pocket in p38 MAPK. Eur J Med Chem 208:0 (2020) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase kinase kinase 20
Synonyms:
M3K20_HUMAN | MAP3K20 | MLK7 | MLTK | Mixed lineage kinase 7 | ZAK
Type:
PROTEIN
Mol. Mass.:
91168.58
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1495629
Residue:
800
Sequence:
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF
  
Inhibitor
Name:
BDBM50556597
Synonyms:
CHEMBL4756586
Type:
Small organic molecule
Emp. Form.:
C30H38N6O3
Mol. Mass.:
530.6611
SMILES:
CCNC(=O)[C@H](CCC1CCCCC1)NC(=O)c1ccc(CNC(=O)c2cnn(c2N)-c2ccccc2)cc1 |r|
Structure:
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