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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50557169
Substrate
n/a
Meas. Tech.
ChEMBL_2057947 (CHEMBL4712948)
IC50
65±n/a nM
Citation
 Bae, EJ; Choi, WG; Pagire, HS; Pagire, SH; Parameswaran, S; Choi, JH; Yoon, J; Choi, WI; Lee, JH; Song, JS; Bae, MA; Kim, M; Jeon, JH; Lee, IK; Kim, H; Ahn, JH Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease. J Med Chem 64:1037-1053 (2021) [PubMed]  Article
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM50557169
Synonyms:
CHEMBL4760939
Type:
Small organic molecule
Emp. Form.:
C25H24ClN3O5
Mol. Mass.:
481.928
SMILES:
Cl.COc1ccc(cc1)-c1cc(ccc1OC)-c1nc(no1)-c1ccc(C[C@H](N)C(O)=O)cc1 |r|
Structure:
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