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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50055012
Substrate
n/a
Meas. Tech.
ChEMBL_62181 (CHEMBL672120)
IC50
3.2±n/a nM
Citation
 Kulkarni, SS; Newman, AH; Houlihan, WJ Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter. J Med Chem 45:4119-27 (2002) [PubMed]
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50055012
Synonyms:
6-(4-Fluoro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,1-a]isoindol-6-ol | 9-(4-Fluoro-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza-fluoren-9-ol | CHEMBL336654
Type:
Small organic molecule
Emp. Form.:
C17H15FN2O
Mol. Mass.:
282.3122
SMILES:
OC1(N2CCCN=C2c2ccccc12)c1ccc(F)cc1 |c:6|
Structure:
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