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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50118293
Substrate
n/a
Meas. Tech.
ChEMBL_62181 (CHEMBL672120)
IC50
16±n/a nM
Citation
 Kulkarni, SS; Newman, AH; Houlihan, WJ Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter. J Med Chem 45:4119-27 (2002) [PubMed]
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50118293
Synonyms:
7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pentaleno[1,2-a]naphthalen-7-ol | CHEMBL133646
Type:
Small organic molecule
Emp. Form.:
C20H15ClN2O
Mol. Mass.:
334.799
SMILES:
OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1 |c:5|
Structure:
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