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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50119507
Substrate
n/a
Meas. Tech.
ChEMBL_124317 (CHEMBL732625)
IC50
3400±n/a nM
Citation
 Laufer, SA; Striegel, HG; Wagner, GK Imidazole inhibitors of cytokine release: probing substituents in the 2 position. J Med Chem 45:4695-705 (2002) [PubMed]
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50119507
Synonyms:
4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methanesulfinyl-phenol | CHEMBL142841
Type:
Small organic molecule
Emp. Form.:
C22H18FN3O2S2
Mol. Mass.:
439.526
SMILES:
CS(=O)c1cc(CSc2nc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)ccc1O
Structure:
Search PDB for entries with ligand similarity: