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Target
Mu-type opioid receptor
Ligand
BDBM50120214
Substrate
n/a
Meas. Tech.
ChEBML_148869
Ki
2555±n/a nM
Citation
 Rinnová, M; Nefzi, A; Houghten, RA Opioid activity of 4-imidazolidinone positional analogues of Leu-Enkephalin. Bioorg Med Chem Lett 12:3175-8 (2002) [PubMed]
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50120214
Synonyms:
(1S,4S)-2-[3-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetyl)-4-benzyl-5-oxo-imidazolidin-1-yl]-4-methyl-pentanoic acid amide | CHEMBL106101
Type:
Small organic molecule
Emp. Form.:
C29H38N6O6
Mol. Mass.:
566.6486
SMILES:
CC(C)C[C@H](N1CN([C@@H](Cc2ccccc2)C1=O)C(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O
Structure:
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