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Target
Cathepsin B
Ligand
BDBM50084655
Substrate
n/a
Meas. Tech.
ChEMBL_2063129 (CHEMBL4718382)
IC50
>100000±n/a nM
Citation
 Jeon, KH; Lee, E; Jun, KY; Eom, JE; Kwak, SY; Na, Y; Kwon, Y Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against ?-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble A? peptide formation. Eur J Med Chem 121:433-444 (2016) [PubMed]  Article
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50084655
Synonyms:
CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | [1-((S)-(S)-1-Formyl-pentylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | [1-(1-Formyl-pentylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | [1-(1-Formyl-pentylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester(calpeptin) | benzyl (S)-4-methyl-1-oxo-1-((S)-1-oxohexan-2-ylamino)pentan-2-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C20H30N2O4
Mol. Mass.:
362.4632
SMILES:
CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O |r|
Structure:
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