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Target
Cathepsin B
Ligand
BDBM50558310
Substrate
n/a
Meas. Tech.
ChEMBL_2063129 (CHEMBL4718382)
IC50
>50000±n/a nM
Citation
 Jeon, KH; Lee, E; Jun, KY; Eom, JE; Kwak, SY; Na, Y; Kwon, Y Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against ?-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble A? peptide formation. Eur J Med Chem 121:433-444 (2016) [PubMed]  Article
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50558310
Synonyms:
CHEMBL4740843
Type:
Small organic molecule
Emp. Form.:
C17H12O3
Mol. Mass.:
264.2754
SMILES:
Oc1ccc(\C=C\C(=O)c2ccco2)c2ccccc12
Structure:
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