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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM50558598
Substrate
n/a
Meas. Tech.
ChEMBL_2063959 (CHEMBL4719212)
IC50
44±n/a nM
Citation
 Balasubramanian, G; Narayanan, S; Andiappan, L; Sappanimuthu, T; Thirunavukkarasu, S; Sundaram, S; Natarajan, S; Sivaraman, N; Rajagopal, S; Nazumudeen, FAA; Saxena, S; Vishwakarma, SL; Narayanan, S; Sharma, GVR; Srinivasan, CV; Kilambi, N In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors. Bioorg Med Chem 24:5702-5716 (2016) [PubMed]  Article
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM50558598
Synonyms:
CHEMBL4756900
Type:
Small organic molecule
Emp. Form.:
C24H24N2O4S
Mol. Mass.:
436.523
SMILES:
COc1ccc(-c2nc(C(=O)NC3CCC(O)CC3)c(C)s2)c2c3ccccc3oc12 |(44.37,-16.57,;43.04,-15.79,;43.03,-14.25,;41.69,-13.48,;41.7,-11.93,;43.03,-11.15,;43.02,-9.61,;44.26,-8.7,;43.78,-7.24,;44.68,-5.99,;44.05,-4.59,;46.21,-6.15,;47.11,-4.9,;46.49,-3.5,;47.39,-2.25,;48.92,-2.41,;49.82,-1.16,;49.55,-3.81,;48.64,-5.06,;42.24,-7.24,;41.33,-6,;41.77,-8.71,;44.36,-11.92,;45.84,-11.45,;46.46,-10.04,;47.99,-9.87,;48.9,-11.12,;48.28,-12.53,;46.75,-12.69,;45.84,-13.95,;44.36,-13.47,)|
Structure:
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