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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM50558599
Substrate
n/a
Meas. Tech.
ChEMBL_2063959 (CHEMBL4719212)
IC50
50±n/a nM
Citation
 Balasubramanian, G; Narayanan, S; Andiappan, L; Sappanimuthu, T; Thirunavukkarasu, S; Sundaram, S; Natarajan, S; Sivaraman, N; Rajagopal, S; Nazumudeen, FAA; Saxena, S; Vishwakarma, SL; Narayanan, S; Sharma, GVR; Srinivasan, CV; Kilambi, N In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors. Bioorg Med Chem 24:5702-5716 (2016) [PubMed]  Article
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM50558599
Synonyms:
CHEMBL4799096
Type:
Small organic molecule
Emp. Form.:
C23H22N2O4S
Mol. Mass.:
422.497
SMILES:
COc1ccc(-c2nc(cs2)C(=O)NC2CCC(O)CC2)c2c3ccccc3oc12 |(61.11,-56.78,;59.77,-56.01,;59.77,-54.47,;58.43,-53.7,;58.43,-52.15,;59.77,-51.37,;59.76,-49.84,;61,-48.93,;60.52,-47.46,;58.97,-47.47,;58.5,-48.94,;61.42,-46.21,;60.79,-44.8,;62.96,-46.36,;63.86,-45.12,;63.23,-43.72,;64.13,-42.47,;65.66,-42.63,;66.56,-41.38,;66.29,-44.03,;65.39,-45.27,;61.1,-52.14,;62.57,-51.66,;63.19,-50.26,;64.72,-50.09,;65.63,-51.34,;65.01,-52.75,;63.48,-52.91,;62.57,-54.17,;61.1,-53.69,)|
Structure:
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