Reaction Details  Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50120938
Substrate
n/a
Meas. Tech.
ChEMBL_61625 (CHEMBL673081)
Ki
136±n/a nM
Citation
 Liégeois, JF; Eyrolles, L; Ellenbroek, BA; Lejeune, C; Carato, P; Bruhwyler, J; Géczy, J; Damas, J; Delarge, J New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors. J Med Chem 45:5136-49 (2002) [PubMed]
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50120938
Synonyms:
(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(8-chloro-11H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-yl)-amine | CHEMBL148353
Type:
Small organic molecule
Emp. Form.:
C26H26ClN5
Mol. Mass.:
443.971
SMILES:
Clc1ccc2Nc3ncccc3N=C(NC3CC4CCC(C3)N4Cc3ccccc3)c2c1 |t:13|
Structure:
Search PDB for entries with ligand similarity: