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Target
Tripeptidyl-peptidase 2
Ligand
BDBM50121285
Substrate
n/a
Meas. Tech.
ChEMBL_211946 (CHEMBL816536)
IC50
>10000±n/a nM
Citation
 Breslin, HJ; Miskowski, TA; Kukla, MJ; Leister, WH; De Winter, HL; Gauthier, DA; Somers, MV; Peeters, DC; Roevens, PW Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles. J Med Chem 45:5303-10 (2002) [PubMed]
Target
Name:
Tripeptidyl-peptidase 2
Synonyms:
TPP2_RAT | Tpp2 | Tripeptidyl aminopeptidase
Type:
PROTEIN
Mol. Mass.:
138287.08
Organism:
Rattus norvegicus
Description:
ChEMBL_211948
Residue:
1249
Sequence:
MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPANWTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQPHDGAAAGDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
  
Inhibitor
Name:
BDBM50121285
Synonyms:
(S)-2-Amino-1-[(S)-2-(5-ethyl-1H-imidazol-2-yl)-2,3-dihydro-indol-1-yl]-propan-1-one | 2-Amino-1-[2-(5-ethyl-1H-imidazol-2-yl)-2,3-dihydro-indol-1-yl]-propan-1-one | CHEMBL337314
Type:
Small organic molecule
Emp. Form.:
C16H20N4O
Mol. Mass.:
284.3562
SMILES:
CCc1cnc([nH]1)[C@@H]1Cc2ccccc2N1C(=O)[C@H](C)N
Structure:
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