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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50559028
Substrate
n/a
Meas. Tech.
ChEMBL_2067504 (CHEMBL4722757)
IC50
21400±n/a nM
Citation
 Kaoud, TS; Mohassab, AM; Hassan, HA; Yan, C; Van Ravenstein, SX; Abdelhamid, D; Dalby, KN; Abdel-Aziz, M NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth. Eur J Med Chem 186:0 (2020) [PubMed]  Article
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50559028
Synonyms:
CHEMBL4740393
Type:
Small organic molecule
Emp. Form.:
C30H25ClN6O2S
Mol. Mass.:
569.077
SMILES:
C\C(=N\O)c1ccc(NC(=O)CSc2nnc(-c3cc(nc4ccccc34)-c3ccc(Cl)cc3)n2CC=C)cc1
Structure:
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