Reaction Details  Report a problem with these data
Target
Dual specificity mitogen-activated protein kinase kinase 7
Ligand
BDBM50553870
Substrate
n/a
Meas. Tech.
ChEMBL_2070431 (CHEMBL4725965)
IC50
5.0±n/a nM
Citation
 Kwong, AJ; Scheidt, KA Non-'classical' MEKs: A review of MEK3-7 inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 7
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4
Type:
Protein
Mol. Mass.:
47502.52
Organism:
Homo sapiens (Human)
Description:
O14733
Residue:
419
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
  
Inhibitor
Name:
BDBM50553870
Synonyms:
CHEMBL4749823
Type:
Small organic molecule
Emp. Form.:
C17H15N3O
Mol. Mass.:
277.3205
SMILES:
Cc1ccc2c(n[nH]c2c1)-c1cccc(NC(=O)C=C)c1
Structure:
Search PDB for entries with ligand similarity: