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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50122912
Substrate
n/a
Meas. Tech.
ChEMBL_124502 (CHEMBL733338)
IC50
270±n/a nM
Citation
 Colletti, SL; Frie, JL; Dixon, EC; Singh, SB; Choi, BK; Scapin, G; Fitzgerald, CE; Kumar, S; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Porter, G; Samuel, K; Schmatz, DM; Schwartz, CD; Shoop, WL; Thompson, CM; Thompson, JE; Wang, R; Woods, A; Zaller, DM; Doherty, JB Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones. J Med Chem 46:349-52 (2003) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mus musculus (mouse)
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50122912
Synonyms:
2-(2,6-Dichloro-phenyl)-6-[2-(2,3-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-2H-pyridazin-3-one | CHEMBL331842
Type:
Small organic molecule
Emp. Form.:
C23H12Cl4N4O
Mol. Mass.:
502.18
SMILES:
Clc1cccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2c(Cl)cccc2Cl)c1Cl |(7.11,-11.19,;6.94,-9.65,;5.53,-9.02,;5.38,-7.48,;6.63,-6.58,;8.03,-7.22,;9.28,-6.33,;10.74,-6.8,;11.65,-5.57,;13.18,-5.42,;13.81,-4.02,;12.91,-2.76,;11.38,-2.92,;10.75,-4.3,;9.28,-4.79,;7.96,-4,;6.62,-4.77,;5.29,-3.99,;5.3,-2.46,;3.97,-1.68,;6.63,-1.69,;7.97,-2.45,;6.63,-.15,;7.97,.62,;9.3,-.15,;7.97,2.16,;6.63,2.93,;5.3,2.16,;5.3,.62,;3.95,-.15,;8.18,-8.74,;9.6,-9.37,)|
Structure:
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