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Target
Integrase
Ligand
BDBM50123467
Substrate
n/a
Meas. Tech.
ChEMBL_90576 (CHEMBL701160)
IC50
1000±n/a nM
Citation
 Zhuang, L; Wai, JS; Embrey, MW; Fisher, TE; Egbertson, MS; Payne, LS; Guare, JP; Vacca, JP; Hazuda, DJ; Felock, PJ; Wolfe, AL; Stillmock, KA; Witmer, MV; Moyer, G; Schleif, WA; Gabryelski, LJ; Leonard, YM; Lynch, JJ; Michelson, SR; Young, SD Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells. J Med Chem 46:453-6 (2003) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50123467
Synonyms:
(3-Benzyl-phenyl)-(3-hydroxy-furo[3,2-b]pyridin-2-yl)-methanone | CHEMBL140319
Type:
Small organic molecule
Emp. Form.:
C21H15NO3
Mol. Mass.:
329.3487
SMILES:
Oc1c(oc2cccnc12)C(=O)c1cccc(Cc2ccccc2)c1
Structure:
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