Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50561253
Substrate
n/a
Meas. Tech.
ChEMBL_2074514 (CHEMBL4730048)
EC50
180±n/a nM
Citation
 Furukawa, H; Miyamoto, Y; Hirata, Y; Watanabe, K; Hitomi, Y; Yoshitomi, Y; Aida, J; Noguchi, N; Takakura, N; Takami, K; Miwatashi, S; Hirozane, Y; Hamada, T; Ito, R; Ookawara, M; Moritoh, Y; Watanabe, M; Maekawa, T Design and Identification of a GPR40 Full Agonist ( J Med Chem 63:10352-10379 (2020) [PubMed]  Article
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50561253
Synonyms:
CHEMBL4786992
Type:
Small organic molecule
Emp. Form.:
C32H37N3O5
Mol. Mass.:
543.6533
SMILES:
COc1ccc(C(=O)N(C)c2ccccn2)c(c1)N1CCC(COc2cccc(c2)C(CC(O)=O)C2CC2)CC1
Structure:
Search PDB for entries with ligand similarity: