Reaction Details  Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50124031
Substrate
n/a
Meas. Tech.
ChEMBL_47426 (CHEMBL662613)
Ki
5260±n/a nM
Citation
 Donkor, IO; Korukonda, R; Huang, TL; LeCour, L Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics. Bioorg Med Chem Lett 13:783-4 (2003) [PubMed]
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50124031
Synonyms:
1-(Toluene-4-sulfonyl)-piperidine-2-carboxylic acid (1-benzyl-2-oxo-ethyl)-amide | CHEMBL163790
Type:
Small organic molecule
Emp. Form.:
C22H26N2O4S
Mol. Mass.:
414.518
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1CCCCC1C(=O)NC(Cc1ccccc1)C=O
Structure:
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