Reaction Details  Report a problem with these data
Target
Endothelin receptor type B
Ligand
BDBM50124477
Substrate
n/a
Meas. Tech.
ChEBML_63688
IC50
903±n/a nM
Citation
 Bolli, MH; Boss, C; Clozel, M; Fischli, W; Hess, P; Weller, T The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists. Bioorg Med Chem Lett 13:955-9 (2003) [PubMed]
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50124477
Synonyms:
4-tert-Butyl-N-[5-(2-methoxy-phenoxy)-6-prop-2-ynyloxy-2-pyrazin-2-yl-pyrimidin-4-yl]-benzenesulfonamide | CHEMBL173465
Type:
Small organic molecule
Emp. Form.:
C28H27N5O5S
Mol. Mass.:
545.609
SMILES:
COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCC#C)-c1cnccn1
Structure:
Search PDB for entries with ligand similarity: