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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50125556
Substrate
n/a
Meas. Tech.
ChEBML_214953
IC50
140±n/a nM
Citation
 Miao, S; Bao, J; Garcia, ML; Goulet, JL; Hong, XJ; Kaczorowski, GJ; Kayser, F; Koo, GC; Kotliar, A; Schmalhofer, WA; Shah, K; Sinclair, PJ; Slaughter, RS; Springer, MS; Staruch, MJ; Tsou, NN; Wong, F; Parsons, WH; Rupprecht, KM Benzamide derivatives as blockers of Kv1.3 ion channel. Bioorg Med Chem Lett 13:1161-4 (2003) [PubMed]
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50125556
Synonyms:
Butyl-carbamic acid 4-[(2-methoxy-benzoylamino)-methyl]-4-phenyl-cyclohexyl ester | CHEMBL277287
Type:
Small organic molecule
Emp. Form.:
C26H34N2O4
Mol. Mass.:
438.5592
SMILES:
CCCCNC(=O)O[C@H]1CC[C@@](CNC(=O)c2ccccc2OC)(CC1)c1ccccc1 |wU:11.11,8.7,(.9,-12.14,;.87,-10.6,;-.46,-9.84,;-.48,-8.3,;-1.82,-7.53,;-1.82,-5.97,;-.48,-5.2,;-3.15,-5.2,;-3.15,-3.66,;-4.48,-2.88,;-4.48,-1.33,;-3.15,-.56,;-1.82,.21,;-.46,-.56,;.87,.21,;.87,1.75,;2.21,-.56,;2.21,-2.11,;3.54,-2.88,;4.89,-2.11,;4.89,-.56,;3.54,.21,;3.54,1.75,;2.21,2.53,;-1.82,-1.33,;-1.82,-2.88,;-4.25,.53,;-3.87,2.01,;-4.97,3.1,;-6.42,2.68,;-6.8,1.21,;-5.72,.12,)|
Structure:
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