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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50125538
Substrate
n/a
Meas. Tech.
ChEMBL_207745 (CHEMBL809694)
IC50
618±n/a nM
Citation
 Miao, S; Bao, J; Garcia, ML; Goulet, JL; Hong, XJ; Kaczorowski, GJ; Kayser, F; Koo, GC; Kotliar, A; Schmalhofer, WA; Shah, K; Sinclair, PJ; Slaughter, RS; Springer, MS; Staruch, MJ; Tsou, NN; Wong, F; Parsons, WH; Rupprecht, KM Benzamide derivatives as blockers of Kv1.3 ion channel. Bioorg Med Chem Lett 13:1161-4 (2003) [PubMed]
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50125538
Synonyms:
CHEMBL16877 | {4-[(2-Methoxy-benzoylamino)-methyl]-4-phenyl-cyclohexyl}-thiocarbamic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C23H28N2O3S
Mol. Mass.:
412.545
SMILES:
COc1ccccc1C(=O)NC[C@]1(CC[C@@H](CC1)NC(=O)SC)c1ccccc1 |wU:12.12,wD:15.19,(5.31,-.94,;6.64,-1.71,;6.64,-3.26,;8,-4.03,;8,-5.6,;6.64,-6.37,;5.31,-5.6,;5.31,-4.03,;3.97,-3.26,;3.97,-1.71,;2.64,-4.03,;1.29,-3.26,;-.05,-4.03,;1.29,-4.8,;1.29,-6.37,;-.05,-7.14,;-1.38,-6.37,;-1.38,-4.8,;-.05,-8.68,;1.29,-9.45,;2.62,-8.68,;1.29,-10.97,;2.62,-11.75,;-1.15,-2.95,;-.77,-1.46,;-1.87,-.38,;-3.34,-.8,;-3.69,-2.28,;-2.62,-3.35,)|
Structure:
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