Reaction Details Report a problem with these data
Target
Polymerase acidic protein
Ligand
BDBM50409787
Substrate
n/a
Meas. Tech.
ChEMBL_220754 (CHEMBL841914)
IC50
18000±n/a nM
Citation
Parkes, KE; Ermert, P; Fässler, J; Ives, J; Martin, JA; Merrett, JH; Obrecht, D; Williams, G; Klumpp, K Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors. J Med Chem 46:1153-64 (2003) [PubMed] Article
More Info.:
Target
Name:
Polymerase acidic protein
Synonyms:
PA | PA_INBLE | RNA-directed RNA polymerase subunit P2
Type:
PROTEIN
Mol. Mass.:
83123.24
Organism:
Influenza B virus (B/Lee/40)
Description:
ChEMBL_220754
Residue:
726
Sequence:
MDTFITKNFQTTIIQKAKNTMAEFSEDPELQPAVLFNICVHLEVCYVISDMNFLDEEGKTYTALEGQGKEQNLRPQYEVIEGMPRNIAWMVQRSLAQEHGIETPRYLADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSDESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEEIEKGIDFKLGQTISKLRNISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLKWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLERYSTLRDQTDPILIMKSEKANENFLWRLWRDCVNTISNEETGNELQKTNYAKWATGDGLTYQKIMKEVAIDDETMYQEEPKIPNKCRVAAWVQAEMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFKIGSLFVSGREKPVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVDQESSIQGYDMTKACFKGDRVNNPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLLLIQALKDRKGPWVFDLEGMYFGVEECISNNPWVIQSAYWFNEWLGIEKEGSKVLESIDEIMDE