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Target
Proteasome subunit beta type-2
Ligand
BDBM50563569
Substrate
n/a
Meas. Tech.
ChEMBL_2083256 (CHEMBL4739047)
IC50
381±n/a nM
Citation
 Wang, J; Liang, B; Chen, Y; Fuk-Woo Chan, J; Yuan, S; Ye, H; Nie, L; Zhou, J; Wu, Y; Wu, M; Huang, LS; An, J; Warshel, A; Yuen, KY; Ciechanover, A; Huang, Z; Xu, Y A new class of ?-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities. Eur J Med Chem 215:0 (2021) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50563569
Synonyms:
CHEMBL4793363
Type:
Small organic molecule
Emp. Form.:
C33H46N4O6
Mol. Mass.:
594.7415
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)C(=O)Nc1ccccc1 |r|
Structure:
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