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Target
Proteasome subunit beta type-1
Ligand
BDBM50563587
Substrate
n/a
Meas. Tech.
ChEMBL_2083257 (CHEMBL4739048)
IC50
361±n/a nM
Citation
 Wang, J; Liang, B; Chen, Y; Fuk-Woo Chan, J; Yuan, S; Ye, H; Nie, L; Zhou, J; Wu, Y; Wu, M; Huang, LS; An, J; Warshel, A; Yuen, KY; Ciechanover, A; Huang, Z; Xu, Y A new class of ?-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities. Eur J Med Chem 215:0 (2021) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50563587
Synonyms:
CHEMBL4765143
Type:
Small organic molecule
Emp. Form.:
C35H50N4O8
Mol. Mass.:
654.7935
SMILES:
COc1cc(NC(=O)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)cc(OC)c1 |r|
Structure:
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