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Target
Casein kinase II subunit alpha
Ligand
BDBM50564383
Substrate
n/a
Meas. Tech.
ChEMBL_2087619 (CHEMBL4768882)
IC50
710±n/a nM
Citation
 Dalle Vedove, A; Zonta, F; Zanforlin, E; Demitri, N; Ribaudo, G; Cazzanelli, G; Ongaro, A; Sarno, S; Zagotto, G; Battistutta, R; Ruzzene, M; Lolli, G A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem 195:0 (2020) [PubMed]  Article
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM50564383
Synonyms:
CHEMBL4783065
Type:
Small organic molecule
Emp. Form.:
C13H6F3N5O4S
Mol. Mass.:
385.278
SMILES:
Oc1ccc(\C=C(/C#N)C(=O)Nc2nnc(s2)C(F)(F)F)cc1[N+]([O-])=O
Structure:
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