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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50126144
Substrate
n/a
Meas. Tech.
ChEMBL_2104319 (CHEMBL4812822)
IC50
50±n/a nM
Citation
 Capochiani de Iudicibus, R; Tomek, P; Palmer, BD; Tijono, SM; Flanagan, JU; Ching, LM Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay. Bioorg Med Chem 39:0 (2021) [PubMed]  Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50126144
Synonyms:
CHEMBL3629569 | US10155972, Compound NewLink 1 | US10233190, Example 1304
Type:
Small organic molecule
Emp. Form.:
C18H22N2O
Mol. Mass.:
282.3801
SMILES:
OC(CC1c2ccccc2-c2cncn12)C1CCCCC1
Structure:
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