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Target
Carbonic anhydrase 2
Ligand
BDBM50569232
Substrate
n/a
Meas. Tech.
ChEMBL_2108570 (CHEMBL4817245)
Ki
42±n/a nM
Citation
 Yamali, C; Sakagami, H; Uesawa, Y; Kurosaki, K; Satoh, K; Masuda, Y; Yokose, S; Ece, A; Bua, S; Angeli, A; Supuran, CT; Gul, HI Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides. Eur J Med Chem 217:0 (2021) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50569232
Synonyms:
CHEMBL4856072
Type:
Small organic molecule
Emp. Form.:
C22H16F3N5O3S2
Mol. Mass.:
519.519
SMILES:
NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1cccs1)C(=O)N\N=C/c1ccc(cc1)C(F)(F)F
Structure:
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