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Target
Acetylcholinesterase
Ligand
BDBM8986
Substrate
n/a
Meas. Tech.
ChEMBL_2110044 (CHEMBL4818719)
IC50
1940±n/a nM
Citation
 Gorecki, L; Misiachna, A; Damborsky, J; Dolezal, R; Korabecny, J; Cejkova, L; Hakenova, K; Chvojkova, M; Karasova, JZ; Prchal, L; Novak, M; Kolcheva, M; Kortus, S; Vales, K; Horak, M; Soukup, O Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors. Eur J Med Chem 219:0 (2021) [PubMed]  Article
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM8986
Synonyms:
7-chloro-1,2,3,4-tetrahydroacridin-9-amine | Tacrine Analogue 3
Type:
Small organic molecule
Emp. Form.:
C13H13ClN2
Mol. Mass.:
232.709
SMILES:
Nc1c2CCCCc2nc2ccc(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: