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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50134838
Substrate
n/a
Meas. Tech.
ChEMBL_154197 (CHEMBL760004)
EC50
320±n/a nM
Citation
 Sauerberg, P; Bury, PS; Mogensen, JP; Deussen, HJ; Pettersson, I; Fleckner, J; Nehlin, J; Frederiksen, KS; Albrektsen, T; Din, N; Svensson, LA; Ynddal, L; Wulff, EM; Jeppesen, L Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo. J Med Chem 46:4883-94 (2003) [PubMed]  Article
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50134838
Synonyms:
(S)-3-{4-[(E)-3-(4'-{(E)-3-[4-((S)-2-Carboxy-2-ethoxy-ethyl)-phenoxy]-1-methyl-propenyl}-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionic acid | CHEMBL144112
Type:
Small organic molecule
Emp. Form.:
C42H46O8
Mol. Mass.:
678.8098
SMILES:
CCO[C@@H](Cc1ccc(OC\C=C(/C)c2ccc(cc2)-c2ccc(cc2)C(\C)=C\COc2ccc(C[C@H](OCC)C(O)=O)cc2)cc1)C(O)=O
Structure:
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