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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50134841
Substrate
n/a
Meas. Tech.
ChEMBL_153868 (CHEMBL759390)
EC50
10500±n/a nM
Citation
 Sauerberg, P; Bury, PS; Mogensen, JP; Deussen, HJ; Pettersson, I; Fleckner, J; Nehlin, J; Frederiksen, KS; Albrektsen, T; Din, N; Svensson, LA; Ynddal, L; Wulff, EM; Jeppesen, L Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo. J Med Chem 46:4883-94 (2003) [PubMed]  Article
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50134841
Synonyms:
(S)-3-{4-[(E)-5-(3-{(E)-5-[4-((S)-2-Carboxy-2-ethoxy-ethyl)-phenoxy]-pent-3-en-1-ynyl}-phenyl)-pent-2-en-4-ynyloxy]-phenyl}-2-ethoxy-propionic acid | CHEMBL345009
Type:
Small organic molecule
Emp. Form.:
C38H38O8
Mol. Mass.:
622.7035
SMILES:
CCO[C@@H](Cc1ccc(OC\C=C\C#Cc2cccc(c2)C#C\C=C\COc2ccc(C[C@H](OCC)C(O)=O)cc2)cc1)C(O)=O
Structure:
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