Reaction Details
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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50135814
Substrate
n/a
Meas. Tech.
ChEMBL_69840 (CHEMBL681891)
Ki
310±n/a nM
Citation
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More Info.:
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Inhibitor
Name:
BDBM50135814
Synonyms:
(Bis-phosphono-methyl)-cyclobutyl-ammonium | (Cyclobutylamino-phosphono-methyl)-phosphonic acid | (cyclobutylamino)methylenediphosphonic acid | CHEMBL54926 | [[(cyclobutyl)amino]methylene]-1,1-bisphosphonate
Type:
Small organic molecule
Emp. Form.:
C5H13NO6P2
Mol. Mass.:
245.1073
SMILES:
OP(O)(O)C(=NC1CCC1)P(O)(O)=O |w:5.5|