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Target
Proteasome subunit beta type-8
Ligand
BDBM50570909
Substrate
n/a
Meas. Tech.
ChEMBL_2113358 (CHEMBL4822208)
IC50
4200±n/a nM
Citation
 Kollár, L; Gobec, M; Szilágyi, B; Proj, M; Knez, D; Ábrányi-Balogh, P; Petri, L; Imre, T; Bajusz, D; Ferenczy, GG; Gobec, S; Keser?, GM; Sosi?, I Discovery of selective fragment-sized immunoproteasome inhibitors. Eur J Med Chem 219:0 (2021) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM50570909
Synonyms:
CHEMBL227686
Type:
Small organic molecule
Emp. Form.:
C8H7ClN2S
Mol. Mass.:
198.673
SMILES:
Cn1c(S)nc2ccc(Cl)cc12
Structure:
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