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Target
Acetylcholinesterase
Ligand
BDBM8987
Substrate
n/a
Meas. Tech.
ChEMBL_2114062 (CHEMBL4822912)
IC50
20±n/a nM
Citation
 Mezeiova, E; Hrabinova, M; Hepnarova, V; Jun, D; Janockova, J; Muckova, L; Prchal, L; Kristofikova, Z; Kucera, T; Gorecki, L; Chalupova, K; Kunes, J; Hroudova, J; Soukup, O; Korabecny, J Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment. Bioorg Med Chem Lett 43:0 (2021) [PubMed]  Article
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM8987
Synonyms:
6-chloro-1,2,3,4-tetrahydroacridin-9-amine | 6-chlorotacrine | 6-chlorotacrine.HCl | CHEMBL486698 | Tacrine Analogue 4
Type:
Small organic molecule
Emp. Form.:
C13H13ClN2
Mol. Mass.:
232.709
SMILES:
Nc1c2CCCCc2nc2cc(Cl)ccc12
Structure:
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