Reaction Details  Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50571228
Substrate
n/a
Meas. Tech.
ChEMBL_2114165 (CHEMBL4823015)
IC50
6590±n/a nM
Citation
 Rastelli, EJ; Sannino, S; Hart, DJ; Sharlow, ER; Lazo, JS; Brodsky, JL; Wipf, P Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway. Bioorg Med Chem Lett 46:0 (2021) [PubMed]  Article
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50571228
Synonyms:
CHEMBL4856668
Type:
Small organic molecule
Emp. Form.:
C29H32N2O5S
Mol. Mass.:
520.64
SMILES:
O=C(CC12CC3CC(CC(C3)C1)C2)NCCCCOc1ccc(cc1)-c1cc2c(s1)C(=O)C(=O)NC2=O |TLB:2:3:6.5.10:8,THB:4:5:8:12.3.11,4:3:6.5.10:8,11:3:6:10.9.8,11:9:6:12.4.3,2:3:6:10.9.8|
Structure:
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