Reaction Details  Report a problem with these data
Target
Somatostatin receptor type 4
Ligand
BDBM50136827
Substrate
n/a
Meas. Tech.
ChEMBL_200837 (CHEMBL807047)
IC50
3.5±n/a nM
Citation
 Grace, CR; Koerber, SC; Erchegyi, J; Reubi, JC; Rivier, J; Riek, R Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR. J Med Chem 46:5606-18 (2003) [PubMed]  Article
Target
Name:
Somatostatin receptor type 4
Synonyms:
SOMATOSTATIN SST4 | SS-4-R | SS4-R | SS4R | SSR4_HUMAN | SST4R | SSTR4 | Somatostatin receptor type 4 (SSTR4)
Type:
Enzyme
Mol. Mass.:
42015.38
Organism:
Homo sapiens (Human)
Description:
P31391
Residue:
388
Sequence:
MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF
  
Inhibitor
Name:
BDBM50136827
Synonyms:
(S)-25-Amino-13-(4-amino-butyl)-22-benzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-7,19-dimethyl-6,12,18-tri(S)-oxo-9,15,21-tri(R)-oxo-24-oxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid | CHEMBL154812
Type:
Small organic molecule
Emp. Form.:
C42H58N10O10S2
Mol. Mass.:
927.101
SMILES:
C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](C)NC1=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: