Reaction Details  Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50139033
Substrate
n/a
Meas. Tech.
ChEMBL_106179 (CHEMBL714598)
EC50
200±n/a nM
Citation
 Richardson, TI; Ornstein, PL; Briner, K; Fisher, MJ; Backer, RT; Biggers, CK; Clay, MP; Emmerson, PJ; Hertel, LW; Hsiung, HM; Husain, S; Kahl, SD; Lee, JA; Lindstrom, TD; Martinelli, MJ; Mayer, JP; Mullaney, JT; O'Brien, TP; Pawlak, JM; Revell, KD; Shah, J; Zgombick, JM; Herr, RJ; Melekhov, A; Sampson, PB; King, CH Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor. J Med Chem 47:744-55 (2004) [PubMed]  Article
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50139033
Synonyms:
1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-2-[4-(2-amino-phenyl)-piperazin-1-yl]-1-(4-chloro-benzyl)-2-oxo-ethyl]-amide | CHEMBL164969
Type:
Small organic molecule
Emp. Form.:
C29H32ClN5O2
Mol. Mass.:
518.05
SMILES:
Nc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1
Structure:
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